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Mitochondrial complex I is considered one of the primary sources of ROS and increased oxidative stress resulting from ROS production is one of the proposed mechanisms for the death of dopaminergic neurons in PD 23

GLUTATHIONE PEROXIDASE PLAYS A CONTRADICTORY ROLE IN HYPERTENSION With respect to hypertension, glutathione peroxidase (GPx) has important functions in the reduction of peroxides that are reported to inactivate vasodilating NO and the decomposition of S-nitrosoglutathione (GSNO), which plays an important role in vascular homeostasis (33)

Green tea extract in concentrated form has been associated with rare but serious liver injury

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